Sunday September 2, 2007
Uncontrolled diarrhea in C. diff. Colitis - what to do

If Diarrhea persists in C. diff. colitis despite treatment with metronidazole (flagyl) - add Cholestyramine 4 grams PO QID.

Caution: Never add cholestyramine with PO vancomycin. It will render the whole treatment ineffective.Bonus Pearl: Wash hands with soap and water if exposure to C.diff. is suspected. The physical action of washing and rinsing hands under such circumstances is recommended because alcohols, chlorhexidine, iodophors, and other antiseptic agents have poor activity against c. diff spores.